Potency of IMP-10 metallo-β-lactamase in hydrolysing various antipseudomonal β-lactams
نویسندگان
چکیده
منابع مشابه
Structural and kinetic studies on metallo-β-lactamase IMP-1.
In an effort to probe for metal binding to metallo-β-lactamase (MβL) IMP-1, the enzyme was overexpressed, purified, and characterized. The resulting enzyme was shown to bind 2 equiv of Zn(II), exhibit significant catalytic activity, and yield EXAFS results similar to crystallographic data previously reported. Rapid kinetic studies showed that IMP-1 does not stabilize a nitrocefin-derived reacti...
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A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapene...
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This study shows for the first time the mechanism of carbapenem resistance of a Klebsiella pneumoniae clinical isolate TJ8 recovered from Tianjin Medical University General Hospital ,China. The modified Hodge test and EDTA synergy test were performed for the screening of carbapenemases and metallo-β-lactamases (MBLs), respectively. Polymerase chain reactions and DNA sequencing confirmed that th...
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1Department of Joint Research Laboratory of Clinical Medicine and 2Department of Quality and Safety in Healthcare, Fujita Health University Hospital, Toyoake 470-1192; 3Department of Pediatrics, Fujita Health University School of Medicine, Toyoake 470-1192; 4Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo 208-0011; and 5Department of Microbiology and Medical Zool...
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Metallo-β-lactamases (MBLs) in Enterobacteriaceae are an increasing problem worldwide. This report describes the isolation of Citrobacter freundii carrying IMP-8 MBL from three patients during the period from March 2012 until March 2013 in Germany. The bla IMP-8 enzyme is predominantly found in Asia, where IMP-8 has spread to various enterobacterial species causing serious infections. To our be...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 2008
ISSN: 0022-2615,1473-5644
DOI: 10.1099/jmm.0.2008/001388-0